Ans B. Use 'compare with' when comparing similar things and 'compare to' for dissimilar things. e.g. Compare my signature with your signature (signatures are two similar things). I compared her smile to the sun (person and sun and dissimilar)
Even if I didn't know the difference btn compare to and compare with, the other answers have issues as shown below
Compared to those who do not, running three days a week saves an average of 14.1 percent on health-care costs each year in the United States.
A. Compared to
those who do not,
running three days a week saves
those should be compared to people not the verb running.
B. Compared with
nonrunners,
people who run three days a week save
Correctly compares nonrunners to people
C. Compared to not
running,
those running for three days a week save
Same as A, comparing verb running to 'those'
D. When compared with those who do not
??, people running three days a week save
When is unnecessary here. Secondly, when compared with those who do not
do what? Sentence shouldn't leave you hanging
E. When compared to
nonrunners,
running three days a week saves
Same as A, cannot compare nonrunners to a verb.