(A) Formulas for cash flow and the ratio of debt to equity do not apply to new small businesses in the same way as they do to established big businesses, because ((they)) are growing and are seldom in equilibrium. - the sentence has two plural nouns - formulas and businesses. Thus, it is not clear that to which one is "they" pointing to. Eliminate.
(B) Because ((they)) are growing and are seldom in equilibrium, ((formulas)) for cash flow and the ratio of debt to equity do not apply to new small businesses in the same way as they do to established big businesses. - can formulas grow ?? Nope. Meaning error. Eliminate.
(C) Because they are growing and are seldom in equilibrium, new small businesses are not subject to the same ((applicability of formulas)) for cash flow and the ratio of debt to equity /as/ ((established big businesses.)) - apart from being a bit wordy, which is a secondary issue, the comparison between applicability of formulas in small businesses and established big business is incorrect. Eliminate
(D) Because new small businesses are growing and are seldom in equilibrium, formulas for cash flow and the ratio of debt to equity do not apply to them in the same way //as to// established big businesses. - pronoun ambiguity and comparison error both eliminated. Keep.
(E) New small businesses are not subject to the applicability of formulas for cash flow and the ratio of debt to equity in the same way ((as)) established big businesses, because they are growing and are seldom in equilibrium. - same error as in C.
Thus, D is best.
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