The Roman Empire expanded to most of southern Europe and the Mediterranean region by the beginning of the first century C.E., bringing the Latin language with it, from which were derived Romance languages, including Spanish, French, Italian, Portuguese, and Romanian.
(A) the Latin language with it, from which were derived Romance
-- 'which' refers to the Roman Empire, which makes no sense. Out.
(B) the Latin language with it, and from which deriving the Romance
-- 'which' refers to the Roman Empire, which makes no sense. Out.
(C) with it the Latin language, from which derive the Romance
Looks good. Keep.
(D) with it the Latin language, from which derives Romance
-- SV agreement error. 'derives' is singular and doesn't match up with plural 'languages'.
(E) with it the Latin language, and deriving from it the Romance
-- 'it' is ambiguous here. Out.
Answer is C.