Original sentence:
The difference in critical accolades afforded to genres of fiction that are predominantly male-focused over the predominantly female-focused have been a topic of extensive discussion, for quite some time, in the field of Gender Studies.
(A) afforded to genres of fiction that are predominantly male-focused over the predominantly female-focused have
Lots of errors on this.
* 'afforded to genes' sounds awkward and un-idiomatic.
* The difference <...> have <... > Subject verb agreement error. It should be 'has', IMO.
* Also, the comparison isn't clear because the phrase "the predominantly female-focused" doesn't clearly relate to "genres of fiction."
(eliminate)
(B) afforded to genres of fiction that are predominantly male-focused over those that are predominantly female-focused have
* Same subject verb error, as in option A.
* afforded to, sounds awkward,
(eliminate)
(C) that favors predominantly male-focused genres of fiction over the predominantly female-focused have
* Same subject verb error as in options A and B.
(eliminate)
(D) afforded to predominantly male-focused genres of fiction over the predominantly female-focused has
* comparison is not clear, the phrase "the predominantly female-focused" doesn't clearly relate to "genres of fiction."
* sounds awkward and un-idiomatic.
(eliminate)
(E) that favors predominantly male-focused genres of fiction over those that are predominantly female-focused has
*only option remaining.
It sounds correct. I will go with option E.