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# Systemic lupus ethematosus (SLE) is an autoimmune disease characterize

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Senior SC Moderator
Joined: 14 Nov 2016
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Systemic lupus ethematosus (SLE) is an autoimmune disease characterize  [#permalink]

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10 Oct 2017, 04:54
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63% (01:47) correct 38% (01:24) wrong based on 32

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Source : PowerScore Reading Comprehension Bible
Systemic lupus ethematosus (SLE) is an autoimmune disease characterized by the aberrant and chronic stimulation of the innate immune system—our first line of defense against infection. Under normal circumstances, immune cells are recruited to sites of infection through the production of chemical factors called cytokines. In patients with SLE, cytokines recruit cells to attack normal, healthy tissues without the presence of an infectious pathogen. This results in the proliferation of antibody-immune complexes that cause inflammation and damage to the kidneys, blood vessels, and skin.

Patients with SLE are often treated with courses of strong immunosupressive drugs, such as cytotoxic drugs, antimalarial compounds and glucocorticoids. While glucocorticoid therapy is considered the most effective course of treatment, it is regrettably transient, requiring more aggressive (and potentially more harmful) treatments, such as high-dose methylprednisolone pulse therapy. Discovering why glucocorticoid therapy fails to provide lasting relief has been the subject of numerous recent studies. The main culprit seems to be the plasmacytoid dendritic cells (pDC)—innate immune cells that circulate in the blood and are found in the peripheral lymphoid organs. While pDCs are normally susceptible to treatment with glucocorticoids, they are resistant to such treatment in patients with SLE. And, since pDCs are responsible for producing the key cytokines involved in SLE pathogenesis, the level of thesecytokines does not substantially decrease with treatment, and symptoms quickly relapse. The precise mechanism by which pDC resistance occurs is still unknown.

1. In the passage the author is primarily concerned with doing which of the following?

(A) outlining the mechanism by which immune cells attack healthy tissues in patients with SLE
(B) demonstrating the difficulties that must be overcome if a satisfactory cure for SLE is to be found
(C) describing the pathogenesis of SLE and explaining why the disease is difficult to treat
(D) showing why one explanation of the difficulties involved in treating SLE falls short in explaining these difficulties
(E) evaluating the evidence supporting the explanation as to why SLE is difficult to treat

2. Which of the following best states the central idea of the passage?

(A) Identifying a cure for SLE requires understanding the precise mechanism by which pDC resistance occurs.
(B) Scientists have made little progress in the treatment of SLE.
(C) Successful treatment of SLE requires reducing the harmful effects of antibody-immune complexes on healthy tissues.
(D) In patients with SLE, the risks associated with the currently available courses of treatment outweigh the benefits of such treatments.
(E) Despite recent advances in our understanding of the immune system, a satisfactory course of treatment for patients with SLE is yet to be found.

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Systemic lupus ethematosus (SLE) is an autoimmune disease characterize  [#permalink]

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11 Oct 2017, 20:10
hazelnut What is the difference between the author is primarily concerned with doing which of the following and central idea of the passage?

Do you have the explanation?
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Resource: GMATPrep RCs With Solution

Systemic lupus ethematosus (SLE) is an autoimmune disease characterize &nbs [#permalink] 11 Oct 2017, 20:10
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